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KMID : 0368820050440050568
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Journal of the Korean Neuropsychiatr Association
2005 Volume.44 No. 5 p.568 ~ p.575
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Event-Related Potential P3a and P3b using 3-Stimulus Auditory "Oddball" Paradigm in the Patients with Schizophrenia.
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Jin Yong-Tak
Park E-Jin
Nam Ji-Min
Han Sang-Ick
Jeon Yang-Whan
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Abstract
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Objectives: Using 3-stimulus auditory "oddball" paradigm reflecting fronto/central and temporo/parietal functions simul-taneously, we examined patients with schizophrenia.
Methods: Fifteen patients with schizophrenia from outpatient clinic and fifteen normal controls from hospital staffs were recruited for the study. To elicit P3a and P3b, 3-stimulus auditory oddball paradigm was employed. The 3-stimulus auditory oddball paradigm was composed of standard tone (1,000 Hz, 75 dB, 80%), target tone (2,000 Hz, 75 dB, 10%) and distracter (White noise, 95 dB, 10%).
Results: P3a and P3b were prominent in fronto/central and temporo/parietal areas, respectively, in both schizophrenics and normal controls. The P300 amplitude in patients with schizophrenia was reduced across P3a and P3b (p<0.01). The P300 latency in patients with schizophrenia was delayed across P3a and P3b (p<0.01).
Conclusion: These results were consistent with frontal and temporo-parietal lobe dysfunctions in schizophrenics. The 3-stimulus auditory paradigm could be applied for patients with schizophrenia and useful for further exploration the disorder.
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KEYWORD
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P300, P3a, P3b, Schizophrenia, 3-stimulus auditory paradigm
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